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Leighton Meester and Hugh Laurie share a meaningful glance in the trailer of their upcoming movie The Oranges.

The 26-year-old actress and her 53-year-old co-star play an unlikely couple in the romantic comedy.

PHOTOS: Check out the latest pics of Leighton Meester

The Oranges, which also features Adam Brody, follows the story of a young woman recently estranged from her fiance who falls for her parents’ best friend and neighbor. The flick hits limited theaters starting October 5. We can’t wait to see it!

Check out the poster for Leighton Meester and Adam Brody‘s upcoming film The Oranges, provided exclusively to JustJared.com!

Here’s the film’s synopsis: David and Paige Walling (Hugh Laurie, Catherine Keener) and Terry and Cathy Ostroff (Oliver Platt, Allison Janney) are best friends and neighbors living on Orange Drive in suburban New Jersey. Their comfortable existence goes awry when prodigal daughter Nina Ostroff (Meester), newly broken up with her fiancé Ethan (Sam Rosen), returns home for Thanksgiving after a five-year absence. Rather than developing an interest in the successful son of her neighbors, Toby Walling (Brody), which would please both families, it’s her parents’ best friend David who captures Nina’s attention.

When the connection between Nina and David becomes undeniable, everyone’s lives are thrown into upheaval, particularly Vanessa Walling’s (Alia Shawkat), Nina’s childhood best friend. It’s not long before the ramifications of the affair begin to work on all of the family members in unexpected and hilarious ways, leading everyone to reawaken to their lives, reassess what it means to be happy, and realize that sometimes what looks like a disaster turns out to be the thing we need.

The Oranges, which premiered last year at the Toronto International Film Festival, is set to be released later this year.

Odette Annable stands close to hubby Dave Annable at the House series finale wrap party held at Cicada on Friday (April 20) in Los Angeles.

The 26-year-old actress, wearing a David Meister dress, was joined by her House co-stars Hugh Laurie, Amber Tamblyn, Omar Epps, Jesse Spencer, Peter Jacobson, Charlyne Yi, Robert Sean Leonard and creator David Shore.

“That’s a wrap folks. [H]ouse… I’ll miss you…” Odette tweeted earlier in the week.

After eight seasons on the air, House creators announced the series ending earlier this year.

You can catch the final episode of House on May 21.

FYI: Dave is wearing Ermenegildo Zegna.

15+ pictures inside of Odette Annable and the cast of House at their wrap party…
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FOX’s long-running medical drama, House, is coming to an end after eight seasons.

“The decision to end the show now, or ever, is a painful one, as it risks putting asunder hundreds of close friendships that have developed over the last eight years – but also because the show itself has been a source of great pride to everyone involved,” executive producers David Shore, Katie Jacobs, and star Hugh Laurie said in a joint statement.

“The producers have always imagined House as an enigmatic creature; he should never be the last one to leave the party. How much better to disappear before the music stops, while there is still some promise and mystique in the air,” they added.

“Everyone at House will bid farewell to the audience and to each other with more than a few tears, but also with a deep feeling of gratitude for the grand adventure they have been privileged to enjoy for the last eight years. If the show lives on somewhere, with somebody, as a fond memory, then that is a precious feat, of which we will always be proud.”

House will air its final episode in April.

ARE YOU SAD that House is ending?

Maggie Gyllenhaal and Hugh Laurie come out to the Hollywood Walk of Fame to celebrate their dear friend, Emma Thompson, as she got her star on Friday (August 6) in Hollywood.

The 51-year-old Nanny McPhee Returns actress got her star in front of the Pig ‘n Whistle pub and celebrated by bringing a pig and a pint of beer onto the red carpet!

Emma announced that she’s planning to take a break from acting for about a year, citing mild depression and saying she’s wanted to take time for her family for a while now.

“Next year, I’m going to take a sabbatical,” she told THR. “I’m not going to fundraise or perform or travel, except in pursuit of new vistas with my family.”

10+ pictures inside of Maggie Gyllenhaal and Hugh Laurie showing Emma Thompson some love in Hollywood…

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Leighton Meester and House actor Hugh Laurie will star together in the upcoming indie The Oranges!

The 23-year-old Gossip Girl hottie will play a young woman who begins a romantic relationship with a much older family friend (Laurie). Filming is expected to start in April in NYC, according to Variety. Catherine Keener is also set to appear in the film, and Julian Farino will direct.

Leighton recently finished work on Love Don’t Let Me Down with Gwyneth Paltrow.

Celebrities left and right are helping the Susan G. Komen for the Cure enhance the quality of life of cancer patients and their families. You too can help raise breast cancer awareness by picking up a promise ring — a symbol for hope, courage, and perseverance. Wear and share the pink promise ring today! You can also visit 25komen.org for more info!

Pictured: Clint Eastwood, Hugh Laurie, Terrence Howard, Toni Braxton, Marcia Gay Harden, Catherine O’Hara, Cuba Gooding Jr., and Greg Kinnear

Other celebrities sporting the Promise Ring and supporting the Komen Foundation: Helen Mirren, Forest Whitaker, Keith Robinson, Dijimon Hounsou, Sophia Bush, Jon Favreau, Cedric the Entertainer, Fred Willard (Images via Susan G. Komen for the Cure/Getty)